Skip to main content

Advertisement

Figure 4 | BMC Evolutionary Biology

Figure 4

From: Molecular evolution of the vertebrate TLR1 gene family - a complex history of gene duplication, gene conversion, positive selection and co-evolution

Figure 4

Distribution of co-evolving amino acids residues mapped onto the surface of TLR2 family protein structures. The protein structures are from Jin et al. (2007) and Kang et al. (2009). Co-evolving amino acids are shown as either network diagrams (displayed using Cytoscape) or mapped onto tertiary structures of protein domains (using PyMOL) for A: human TLR1/TLR2 and B: mouse TLR6/TLR2 complexes. In the network diagrams the TLR1/TLR6 and TLR2 amino acids are depicted by ellipse and rectangle shapes, respectively. Cyan, pale green and pink amino acid residues represent the ligand binding domain, α helices near the ligand binding domain and the extracellular domain, respectively. The color of lines in A(i) and B(i) represents the correlation coefficients of co-evolving amino acids. In the tertiary structures the peptide fragments from TLR1/TLR6 and TLR2 are in pale green and yellow, respectively. Amino acids joined by the same color of the broken lines are clustered to the one evolutionary group.

Back to article page