Table 1 Proteins considered in this analysis
From: Protein coalitions in a core mammalian biochemical network linked by rapidly evolving proteins
Protein (Abbreviation) | PID (Hs)1 | Path-way2 | Class3 | H-M4 |
|---|---|---|---|---|
Glucokinase (GK) | P35557 | G | U | 98.3 |
6-phosphofructokinase (F6P) | P17858 | G | U | 97.0 |
fructose-bisphosphate aldolase (A) (FBa) | P04075 | G | U | 98.9 |
fructose-bisphosphate aldolase (B) (FBb) | P05062 | G | U | 99.7 |
fructose-bisphosphate aldolase (C) (FBc) | P09972 | G | U | 98.6 |
glyceraldehyde 3-phosphate dehydrogenase (GAPD) | P04406 | G | U | 97.0 |
bisphosphoglycerate phosphatase (1) (PGP1) | P18669 | G | U | 99.6 |
bisphosphoglycerate phosphatase (2) (PGP2) | P15259 | G | U | 95.2 |
Pyruvate kinase (PK) | P30613 | G | U | 95.5 |
Lactate dehydrogenase A (LDHa) | P00338 | G | U | 97.6 |
Lactate dehydrogenase B (LDHb) | P07195 | G | U | 99.1 |
Pyruvate Dehydrogenase Complex A (PDCa) | P08559 | T | U | 99.5 |
Pyruvate Dehydrogenase Complex B (PDCb) | P11177 | T | U | 97.5 |
Pyruvate Dehydrogenase Complex C (PDCc) | P29803 | T | U | 87.2 |
Citrate Synthase (CS) | O75390 | T, P | U | 97.4 |
Aconitase (ACO) | Q99798 | T, P | U | 98.8 |
Isocitrate Dehydrogenase (NAD+) (A) (IDHa) | P50213 | T, P | U | 98.6 |
Isocitrate Dehydrogenase (NAD+) (G) (IDHg) | P51553 | T, P | U | 97.2 |
Oxoglutarate Dehydrogenase Complex (OGDC) | Q02218 | T | U | 94.1 |
Succinyl-CoA synthetase A (SCSa) | P53597 | T | U | 97.0 |
Succinyl-CoA synthetase B (SCSb) | Q96I99 | T | U | 96.1 |
Succinate Dehydrogenase A (SDHa) | P31040 | T | U | 94.0 |
Succinate Dehydrogenase B (SDHb) | P21912 | T | U | 97.0 |
Fumarase (FM) | P07954 | T, N | U | 95.3 |
Malate Dehydrogenase (mitochondrion & cytosol) (MDH) | P40926 | T, N | U | 97.6 |
Alanine Transaminase (AlaTA) | P24298 | N | U | 92.5 |
Aspartate Transaminase (AspTA) | P00505 | N | U | 98.4 |
Nucleoside Diphosphate Kinase (NDK) | O00746 | T | U | 87.8 |
NADH: Ubiquinone oxidoreductase 1 (MT-ND1) | O15239 | R | E | 92.9 |
NADH: Ubiquinone oxidoreductase 2 (MT-ND2) | O43678 | R | E | 93.9 |
NADH: Ubiquinone oxidoreductase 3 (MT-ND3) | O95167 | R | E | 88.1 |
NADH: Ubiquinone oxidoreductase 4 (MT-ND4) | O00483 | R | E | 92.7 |
NADH: Ubiquinone oxidoreductase 5 (MT-ND5) | Q16718 | R | U | 91.3 |
NADH: Ubiquinone oxidoreductase 6 (MT-ND6) | P56556 | R | U | 90.8 |
NADH: Ubiquinone oxidoreductase 7 (MT-ND7) | O95182 | R | E | 95.5 |
NADH: Ubiquinone oxidoreductase 8 (MT-ND8) | P51970 | R | U | 94.7 |
NADH: Ubiquinone oxidoreductase 9 (MT-ND9) | Q16795 | R | U | 87.3 |
Ubiquinol: Cytochrome c Oxidoreductase H (UQCRH) | P08574 | R | U | 92.3 |
Ubiquinol: Cytochrome c Oxidoreductase I (UQCRI) | P47985 | R | U | 94.5 |
Ubiquinol: Cytochrome c Oxidoreductase Q (UQCRQ) | O14949 | R | E | 85.2 |
Ubiquinol: Cytochrome c Oxidoreductase R1 (UQCRR1) | O14957 | R | M | 92.7 |
Ubiquinol: Cytochrome c Oxidoreductase C2 (UQCRC2) | P22695 | R | U | 93.2 |
Cytochrome c Oxidase 6B1 (Cox6B1) | P14854 | R | E | 96.5 |
Cytochrome c Oxidase 2* (Cox2) | P00403 | R | U | 86.8 |
Cytochrome c Oxidase 8a (Cox8a) | P10176 | R | V | 85.5 |
Cytochrome c Oxidase 5A (Cox5a) | P20674 | R | U | 88.0 |
Cytochrome c Oxidase 4A (Cox4a) | P13073 | R | E | 89.9 |
Cytochrome c Oxidase 6C (Cox6c) | P09669 | R | M | 86.7 |
Cytochrome c Oxidase 7B (Cox7b) | P24311 | R | V | 88.8 |
Cytochrome c Oxidase 1* (Cox1) | P00395 | R | U | 95.5 |
Cytochrome c Oxidase 7R (Cox7r) | O14548 | R | E | 93.0 |
Cytochrome c Oxidase 7C (Cox7c) | P15954 | R | E | 88.9 |
Oxoglutarate Carrier (OGC) | Q02978 | N, P | E | 97.8 |
Citrate Carrier (CIC) | P53007 | M | E | 96.5 |
Nicotinamide nucleotide transhydrogenase (NNT) | Q13423 | S | U | 96.2 |
Glutathione reductase (GSSGR) | P00390 | S | U | 89.3 |
Glutathione peroxidase (GSSGP) | P07203 | S | U | 90.6 |
Glycerol-3-phosphate dehydrogenase (FAD dependent) (GUT2P) | P43304 | N | U | 97.0 |
Glycerol-3-phosphate dehydrogenase (NAD+) (G3PD) | P21695 | N | U | 96.8 |
Malate Dehydrogenase (oxaloacetate-decarboxylating) (NADP+) X (MEx) | P48163 | P | U | 94.9 |
Malate Dehydrogenase (oxaloacetate-decarboxylating)(NADP+) N (Men) | Q16798 | P | U | 96.4 |
ATP/ADP Carrier 2 (AAC) | P05141 | M | U | 99.3 |
cytosolic Isocitrate Dehydrogenase (NADP+) P (IDHcp) | P48735 | P | U | 82.0 |
cytosolic Isocitrate Dehydrogenase (NADP+) C (IDHcc) | O75874 | P | U | 97.8 |
Pyruvate Carboxylase (PC) | P11498 | T, P | U | 98.6 |
ETF:Q oxidoreductase (ETF-QO) | Q16134 | N | U | 95.8 |
Manganese-dependent superoxide dismutase 2 C (SOD2c) | P00441 | S | U | 88.9 |
Manganese-dependent superoxide dismutase 2 M (SOD2 m) | P04179 | S | U | 91.9 |
Manganese-dependent superoxide dismutase 2 E (SOD2e) | P08294 | S | U | 75.2 |