Evolution of ligand specificity in vertebrate corticosteroid receptors

Table 2 Corticosteroid receptor ligand specificity

	Aldo	DOC	Cortisol	Dex	S	E
Hagfish CR [2]	+	+	+	N.A.	+	N.A.
Lamprey CR [2]	+	+	+	N.A.	+	N.A.
Skate MR [2, 25]	+	+	+		+	N.A.
Mouse MR	+	+	+		+	0
Rainbow Trout MR [10]	+	+	+		+	N.A.
Burton's cichlid MR [2, 12]	+	N.A.	+		N.A.	N.A.
Daffodil cichlid MR	+	N.A.	+		N.A.	N.A.
Midshipman MR	+	+	+		+	0
Skate GR [2, 25]	+	+	+	N.A.	+
Mouse GR	0 ¹	0	+	+	0	0
Rainbow trout GR1 [13]	0	0	+	+	0	0
Burton's cichlid GR1 [2, 12]	+/0 ²	N.A.	+	N.A.	N.A.	N.A.
Daffodil cichlid GR1	+	N.A.	+	N.A.	N.A.	N.A.
Midshipman GR1	0	0	+	+	0	0
Rainbow trout GR2 [13]	0 ³	0	+	+	+	0
Burton's cichlid GR2 [12]	+	N.A.	+	N.A.	N.A.	N.A.
Daffodil cichlid GR2	0	N.A.	+	N.A.	N.A.	N.A.
Midshipman GR2	+	+	+	+	0	0

Note: Aldo, aldosterone; DOC, 11-deoxycorticosterone; Dex, dexamethasone; Reichstein's compound S, 11-deoxycortisol; Reichstein's compound E, cortisone. + and 0 indicate activation or lack of activation, respectively, by each ligand to induce transactivational activity at concentrations of ≤ 10^-7 M. N.A. indicates that the data are not available. Data from previous studies are indicated by the citations following the receptor type. The MR response to dexamethasone is excluded because of the confounding dexamethasone paradox [53].
¹Activity at >10^-7 M;
²Disagreement between previous studies;
³Possible low activation at 10^-6 M

ISSN: 2730-7182