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Figure 1 | BMC Evolutionary Biology

Figure 1

From: Characterization of the tandem CWCH2 sequence motif: a hallmark of inter-zinc finger interactions

Figure 1

Structures of tCWCH2 sequence motifs from three different proteins. (A) Superimposition of the 3D structures of ZIC3, GLI1, and Zap1 tCWCH2 is shown in stereo view. Backbones of the protein structures are indicated by the flat ribbon model. The side chains of two conserved tryptophan residues in tCWCH2 are indicated by the stick model. Red = ZIC3 (PDBID: 2RPC); Blue = GLI1 (PDBID: 2GLI); Green = Zap1 (PDBID: 1ZW8). (B) Amino acid sequence alignment of the tCWCH2 regions. Zinc-chelating cysteine and histidine residues are shown in gray boxes and conserved tryptophan residues are shown in white letters with black boxes. In (A) and (B), the gray lines with arrowheads indicate the sequence between the two CWCH2 motifs (linker sequence).

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