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Table 3 Degrees and duplicabilities of the genes in the yeast PIN belonging to each functional category

From: Difference in gene duplicability may explain the difference in overall structure of protein-protein interaction networks among eukaryotes

GO biological process category

Mean degreea

Mean duplicabilitya

# of proteins

Lipid metabolic process

2.2

0.79 (---)

127

Cellular respiration

2.2

0.34

57

Vitamin metabolic process

2.6

1.33 (+)

51

Cofactor metabolic process

2.6

0.72

86

Translation

2.6

0.70

167

Aromatic compound metabolic process

2.9

0.50

42

Heterocycle metabolic process

2.9

0.40

48

Carbohydrate metabolic process

3.1

1.80 (+++)

97

Amino acid and derivative metabolic process

3.6

0.81

124

Generation of precursor metabolites and energy

3.9

0.86

95

Sporulation

4.0

0.66

84

Cell wall organization and biogenesis

4.1

1.42 (+++)

129

Response to chemical stimulus

4.1 (+)

1.05 (+++)

271

Protein modification process

4.1 (++)

0.72

368

Cellular homeostasis

4.2

1.12

63

DNA metabolic process

4.5

0.42 (---)

244

Protein catabolic process

4.7 (+)

0.31 (---)

119

Meiosis

4.7 (++)

0.27 (-)

104

Transport

4.8 (+++)

1.93 (+)

649

Response to stress

4.8 (+++)

0.72

348

Organelle organization and biogenesis

4.9 (+++)

0.46 (---)

947

Vesicle-mediated transport

5.3 (+++)

0.56

261

Cell cycle

5.3 (+++)

0.49

292

Pseudohyphal growth

5.4

0.83

50

Signal transduction

5.6 (+++)

1.08 (+)

168

Membrane organization and biogenesis

5.7 (+++)

0.64

149

RNA metabolic process

6.0 (+++)

0.18 (---)

496

Cytokinesis

6.1 (+++)

0.62

91

Transcription

6.3 (+++)

0.22 (---)

178

Conjugation

6.4 (+++)

0.71

89

Anatomical structure morphogenesis

6.8 (+++)

0.63

115

Cell budding

7.5 (+++)

0.78

70

All proteins in the yeast PIN

3.7

0.92

3,891

  1. NOTE. Functional categories containing five or more proteins are shown. Genes in the MIPS database were used.
  2. a. The mean among the proteins contained in each functional category. +++, ++, and + (or ---, --, and -) indicates that a given value is significantly higher (or lower) with P < 0.001, P < 0.01, and P < 0.05, respectively, by the Wilcoxon rank-sum two-sample test with the Bonferroni correction.