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Table 1 X. tropicalis ADAM genes identified in this study

From: Conservation and divergence of ADAM family proteins in the Xenopus genome

Encoded ADAM

GenBank accession

% identity with closest

human homologue

% identity with

X. laevis orthologue

Expression pattern*

ADAM9

HM467820

69

91

Widespread

ADAM10

DQ287908

82

93

Widespread

ADAM10-like

HM483366

43 (with ADAM10)

ND

Widespread

ADAM11†

HM467821

76

95

Tailbud stage head; tadpole; metamorphic tail; adult brain (high level)

ADAM12

DQ393787

66

ND

Gastrula; neurula; tadpole

ADAM13/33

DQ393788

53 (with ADAM33)

91

Gastrula; neurula; tadpole; metamorphic tail; adult spleen

ADAM15†

HM467822

44

81

Gastrula; metamorphic limb; adult brain, lung, testis

ADAM17

HM483367

68

91

Neurula; adult brain, testis, oviduct

ADAM19

DQ393789

59

85

Gastrula; neurula; tadpole

ADAM22†Δ

HM467823

HM467824

HM467825

71

83

Tadpole; metamorphic brain/spinal cord; adult brain (high level), testis

ADAM23†

HM467826

72

ND

Tadpole; adult brain (high level), spleen, kidney, thymus

ADAM28a‡

HM467827

47

82

Widespread

ADAM28b‡

HM467828

44

ND

Neurula; tadpole; adult spleen, bone, kidney

  1. * Expression patterns were estimated by the presence of ESTs (full or partial) in different organs and/or developmental stages, as deposited in GenBank. "Widespread" was assigned when ESTs are present in multiple (>20) organs, and "high level" was assigned when multiple (>20) EST entries are present in a single organ at a single developmental stage and account for >50% of all ESTs found in GenBank.
  2. † ADAMs predicted to be proteolytically inactive.
  3. ‡ Two additional adam28 homologues (adam28c and d) were identified on Scaffold 30, but full-length cDNA clones have not been obtained.
  4. Δ Three alternatively spliced isoforms of X. tropicalis ADAM22 were identified in this study. ISO1 (HM467823) was used to calculate sequence identities here.
  5. ND: not determined.