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Table 1 X. tropicalis ADAM genes identified in this study

From: Conservation and divergence of ADAM family proteins in the Xenopus genome

Encoded ADAM GenBank accession % identity with closest human homologue % identity with X. laevis orthologue Expression pattern*
ADAM9 HM467820 69 91 Widespread
ADAM10 DQ287908 82 93 Widespread
ADAM10-like HM483366 43 (with ADAM10) ND Widespread
ADAM11 HM467821 76 95 Tailbud stage head; tadpole; metamorphic tail; adult brain (high level)
ADAM12 DQ393787 66 ND Gastrula; neurula; tadpole
ADAM13/33 DQ393788 53 (with ADAM33) 91 Gastrula; neurula; tadpole; metamorphic tail; adult spleen
ADAM15 HM467822 44 81 Gastrula; metamorphic limb; adult brain, lung, testis
ADAM17 HM483367 68 91 Neurula; adult brain, testis, oviduct
ADAM19 DQ393789 59 85 Gastrula; neurula; tadpole
ADAM22†Δ HM467823 HM467824 HM467825 71 83 Tadpole; metamorphic brain/spinal cord; adult brain (high level), testis
ADAM23 HM467826 72 ND Tadpole; adult brain (high level), spleen, kidney, thymus
ADAM28a HM467827 47 82 Widespread
ADAM28b HM467828 44 ND Neurula; tadpole; adult spleen, bone, kidney
  1. * Expression patterns were estimated by the presence of ESTs (full or partial) in different organs and/or developmental stages, as deposited in GenBank. "Widespread" was assigned when ESTs are present in multiple (>20) organs, and "high level" was assigned when multiple (>20) EST entries are present in a single organ at a single developmental stage and account for >50% of all ESTs found in GenBank.
  2. ADAMs predicted to be proteolytically inactive.
  3. Two additional adam28 homologues (adam28c and d) were identified on Scaffold 30, but full-length cDNA clones have not been obtained.
  4. Δ Three alternatively spliced isoforms of X. tropicalis ADAM22 were identified in this study. ISO1 (HM467823) was used to calculate sequence identities here.
  5. ND: not determined.